RAF Typhoon FGR4s have conducted a mission with French aircraft in a joint strike targeting an underground arms cache in Syria used by the IS group, per a report from the British defence ministry.
The site, located using surveillance, was assessed as containing munitions and bombs, the announcement noted, and was located in hills just above the historic site of Palmyra in central Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to target a number of approach shafts down to the site... early reports suggest the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the attack conducted Saturday night and all the aircraft returned safely, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
IS - also known as ISIS - established jihadist rule over large swathes of both Syria and Iraq until 2019.
"This strike demonstrates British leadership, and commitment to stand shoulder to shoulder with allied nations, to stamp out any revival of the terrorist group and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the Defence Secretary said.
UK warplanes have conducted surveillance missions over Syria to "deter any attempted resurgence" of IS subsequent to its defeat at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of our armed forces involved in this strike for their professionalism and their bravery," Healey said. "Including them were thousands of British personnel stationed over Christmas and New Year. This operation, to take out terrorist threats who endanger our safety, demonstrates how British military are always on standby, throughout the year, ensuring Britain's security domestically and strong abroad."
During December, the US military executed what it called a "large-scale strike" targeting Daesh sites in the country, following an assault claimed the lives of two US servicemembers and a civilian interpreter in the Palmyra area.
The United Nations says Islamic State still has an estimated 5,000 to 7,000 militants in Iraq and Syria.